This image shows the 5,372 samples as dots colour-coded for the six major clusters identified by comparing gene expression profiles. The left and right panels of the figure are projections of the same three-dimensional shape viewed from two different perspectives. (Credit: Brazma / EMBL)
Prabhupada, San Francisco, July 17, 1975: ..There is a big government within this universe. But those who are thinking very poorly, without any advanced knowledge, atheist, they think that everything is coming automatically. Anisva, anisvara rahuh. They say there is no isvara, supreme ruler, and everything is happening by nature. But they cannot explain what is nature. At least, they have to admit nature is a power which is controlling him. We are not independent of the laws of nature. That is not possible. Even if you accept nature, then you are under the control of nature. That is a fact. Who is controlling nature, that you may not know because your knowledge is very poor. But nature is controlling you, that you can understand, everyone can understand. You cannot supersede the laws of nature. Daivi hy esa gunamayi mama maya duratyaya [Bg. 7.14]. Just like ordinary criminal, thief. The police is chastising him. He does not think that there is any other power over the police. He thinks the police is the father and mother, and he is poor class. He does not know that police is not the supreme power. The supreme power is the president or the minister of law and order. He thinks, “This constable is everything.” So poor-class thinking, they think nature is everything. But any way, everyone is under the control of nature.
prakrteh kriyamanani gunaih karmani sarvasah ahankara-vimudhatma kartaham iti manyate [Bg. 3.27]
The so-called scientists, thinker, they are thinking that “We are everything. We can create, and we can control over the nature.” These are all mad thinking. It is not possible. Nobody has ever been able to control over the nature, what to speak of understanding God. God is the controller of nature. Mayadhyaksena prakrtih suyate sa- caracaram [Bg. 9.10] Nature is not independent.
So anyway, we are dependent on the laws of nature. That nobody can deny, even the greatest scientist, he cannot also deny. And because we are under the control of the laws of nature, we must admit, if we are sane man, that there is a system of ruling. If we deny the supreme ruler, we may do it madly, but there must be a systematic action, reaction. More
Researchers Present Global Map of Human Gene Expression
ScienceDaily (Apr. 8, 2010) — Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties.
By integrating gene expression data from an unprecedented variety of human tissue samples, Alvis Brazma and his team at the European Bioinformatics Institute, an outstation of the European Molecular Biology Laboratory (EMBL), and their collaborators have for the first time produced a global map of gene expression. The full analysis behind this unique view of the genetic activities determining our appearance, function and behaviour is published in Nature Biotechnology.
The analysis used data collected from 163 laboratories worldwide involving 5,372 human samples from various tissues, cell types and diseases. Most transcriptomics experiments compare gene expression in only a few cell types or conditions and although technically challenging, integrating this data on a large-scale has created a new way for scientists to explore gene expression. The analysis is visualised as a map subdividing the human gene expression space into six distinct major groups or ‘continents’.
The continents emerged by grouping samples with similar gene expression signatures. This established the identity of the six groups: brain; muscle; hematopoietic (blood related); healthy and tumour solid tissues; cell lines derived from solid tissues; and partially differentiated cells. By visualising these subsets in 3D, comparisons can be made on the degree of similarity in the gene expression profiles on each grouping. For example, analysis of the continents showed that cell lines are usually more similar to each other than to their tissue of origin.
A new bioinformatics service allowing anyone to explore this expression map has been developed by the European Bioinformatics Institute as part of the ArrayExpress Gene Expression Atlas resource (www.ebi.ac.uk/gxa/).
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